The Wengryniuk lab
  • W Lab
  • Research
  • People
    • About Sarah
    • Pictures
  • Publications
  • Teaching
  • Outreach
  • News
Picture
The W Lab, Spring Graduation 2019

The W Lab @ Temple

Our lab aims to develop a multifaceted research program that leverages a unique class of hypervalent iodine reagents in novel approaches to "umpolung" or reverse-polarity chemistry, Our research encompasses reagent development, new synthetic methods, and the application of these tools to the synthesis of natural products containing challenging medium-ring heterocycles. We aim to bridge the gap between the three-dimensional molecular complexity of nature and the planar aromatic structures of small molecule libraries by introducing simplified strategies and novel disconnections of these valuable architectures. 

W Lab News
The Wengryniuk Lab will yet again be participating as judges at the VIRTUAL George Washington Carver Science Fairs this year!
Want to join us for a fun filled day of talking to kiddos about science and fostering excitement in STEM??
Elementary Fair and Secondary Fair are going to be hosted online, more details to follow!
Go here for more information and to sign up!!
January 2021: The Wengryniuk Lab welcomes new first year student Angelika Baran!
​Welcome to the team!

Breaking News and Events

January 12, 2021: Xiao's Synpacts article examining the regioselective synthesis of Ortho-Quinones and Ortho-Quinols from Phenols using I(V) Reagents is up on Synlett! 
​This Perspective was an invited submission following up on our ACIE paper in 2019 on dearomatization using our I(V) Bi(N)-HVI reagents (Check that out here!). It highlights the unique utility of I(V) reagents for the regioselective ortho-oxidation of phenols, covering everything from reagent and methods development to total synthesis applications!  


Picture
January 3, 2020: Felipe and Wendy's paper entitled "Direct C–H alpha-Arylation of Enones with ArI(O2CR)2 Reagents" has been accepted for publication in JACS: https://doi.org/10.1021/jacs.9b11282)! 
​
Picture
This work outlines a novel approach to the direct C–H alpha-arylation of enones, a remaining challenge in organic synthesis. Alpha-aryl enones are valuable structural motifs and synthetic intermediates, however, perhaps surprisingly in the age of C–H functionalization, there remains no general strategy for the direct enone C–H arylation. By leveraging the unique reactivity of in situ generated b-pyridinium silyl enol ethers, Felipe and Wendy developed an arylation strategy using readily accessible ArIX2 reagents which proceeds via a reductive [3,3]-iodonium Claisen. A particularly powerful feature of this chemistry is that the entire aryl iodide moiety is transferred intact, making it highly atom economical and installing a valuable functional handle for downstream manipulations. This work builds on recent beautiful work from Shafir by extending arylative iodonium Claisen reaction to non-malonate derivatives and appears to be enabled by dual steric and electronic modulation by the beta-pyridinium moiety. This unique reactivity is the subject of ongoing investigations in our group. Congrats to Felipe (Y4) and Wendy (Temple Undergrad!) on some great work!
Powered by Create your own unique website with customizable templates.
  • W Lab
  • Research
  • People
    • About Sarah
    • Pictures
  • Publications
  • Teaching
  • Outreach
  • News