The W Lab, Spring Graduation 2019
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The W Lab @ TempleOur lab aims to develop a multifaceted research program that leverages a unique class of hypervalent iodine reagents in novel approaches to "umpolung" or reverse-polarity chemistry, Our research encompasses reagent development, new synthetic methods, and the application of these tools to the synthesis of natural products containing challenging medium-ring heterocycles. We aim to bridge the gap between the three-dimensional molecular complexity of nature and the planar aromatic structures of small molecule libraries by introducing simplified strategies and novel disconnections of these valuable architectures.
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January 12, 2021: Xiao's Synpacts article examining the regioselective synthesis of Ortho-Quinones and Ortho-Quinols from Phenols using I(V) Reagents is up on Synlett!
This Perspective was an invited submission following up on our ACIE paper in 2019 on dearomatization using our I(V) Bi(N)-HVI reagents (Check that out here!). It highlights the unique utility of I(V) reagents for the regioselective ortho-oxidation of phenols, covering everything from reagent and methods development to total synthesis applications! |
January 3, 2020: Felipe and Wendy's paper entitled "Direct C–H alpha-Arylation of Enones with ArI(O2CR)2 Reagents" has been accepted for publication in JACS: https://doi.org/10.1021/jacs.9b11282)!
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