The W Lab, Summer 2023
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The W Lab @ TempleSustainable Approaches to Reversed-Polarity Transformations
In the W lab, our diverse team of researchers work on a multifaceted research program that focused on sustainable approaches to "umpolung" or reverse-polarity chemistry. Our research encompasses reagent development, new synthetic methods, catalysis, and the application of these tools to the synthesis of natural products. We are particularly interested in methods that allow rapid access to molecular diversity, either via modular small molecule library synthesis or late-stage natural product derivatization.
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W Lab News
Summer 2024: Congratulations to our undergraduate Zach Christidhis for graduating with his B.S. in chemistry. He will be pursuing his graduate studies at Johns Hopkins in the fall!
Summer 2024: Congratulations to Bill Motsch for successfully defending his thesis and starting his post-doc at GSK!
Temple O.W.L.S
Are you woman in STEM at Temple? Looking for resources, networking and outreach opportunities?
Visit our website to learn more about the Temple O.W.L.S.
Incoming female first years: Be sure to check out our O.W.L.S. Mentorship Program!
Visit our website to learn more about the Temple O.W.L.S.
Incoming female first years: Be sure to check out our O.W.L.S. Mentorship Program!
Recent Research Highlights
C2 and C4 via I(III)!
Recently we serendipitously discovered a unique quinoline C-H amination using Py-HVI reagents. We were delighted to discover that our favorite reagent could aminate the C4- and C2-H bonds in quinoline derivatives. This method does not require pre-activated N-oxides and allows us to access the somewhat elusive C4 position of benzofused azines. Because of this strange reactivity we went across the globe to collaborate with the team of Dutton and Wilson to better understand this reaction computationally. We are excited to see what new and unexpected chemistry we will uncover with N-HVI next!
Recently we serendipitously discovered a unique quinoline C-H amination using Py-HVI reagents. We were delighted to discover that our favorite reagent could aminate the C4- and C2-H bonds in quinoline derivatives. This method does not require pre-activated N-oxides and allows us to access the somewhat elusive C4 position of benzofused azines. Because of this strange reactivity we went across the globe to collaborate with the team of Dutton and Wilson to better understand this reaction computationally. We are excited to see what new and unexpected chemistry we will uncover with N-HVI next!
Good for more than just the Zincke
N-aryl pyridinium salts have been known for over a hundred years, the methods for their syntheses remained stagnant until 2013. In the last decade, a variety of new methods have emerged to synthesize these synthetically valuable intermediate. Recently, we published a review highlighting the modern efforts in the area of N-aryl pyridinium salt syntheses and applications.
N-aryl pyridinium salts have been known for over a hundred years, the methods for their syntheses remained stagnant until 2013. In the last decade, a variety of new methods have emerged to synthesize these synthetically valuable intermediate. Recently, we published a review highlighting the modern efforts in the area of N-aryl pyridinium salt syntheses and applications.
