July 17, 2019: Myriam and Sophie's paper entitled "Chemoselective Oxidation of Equatorial Alcohols with N-Ligated Lambda-3 Iodanes" has been accepted for publication in Organic Letters: https://doi.org/10.1021/acs.orglett.9b02018)!
This work fills a remaining gap in the selective functionalization of complex scaffolds: the chemoselective oxidation of equatorial over axial alcohols! Using two mild, operationally simple procedures, the simple pyridine ligated N-HVI "Py-HVI" enables the general oxidation of alcohols to ketones with an I(III)-reagent, which offers safety and practical advantages over typical I(V) and Cr(VI) oxidants. The conformational selectivity is explored in detail and a model for predicting the relative rates of oxidation is provided. We hope that this protocol provides a new tool for complex molecule total synthesis! Congrats to Myriam and Sophie on some great work!
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